肠球菌对氨基糖苷类高水平耐药机制的临床研究进展

Clinical research progress on the mechanisms of high level aminoglycoside resistance in enterococcus

耐氨基糖苷类高水平肠球菌(HLAR)是医院感染的重要病原菌,氨基糖苷类修饰酶(AME)是肠球菌对氨基糖苷类高水平耐药的主要机制,其中N-乙酰转移酶(AAC)、O-核苷转移酶(ANT)和O-磷酶转移酶(APH)是参与耐药基因表达的主要氨基糖苷类修饰酶类。现就氨基糖苷类修饰酶的耐药基因及其耐药基因的传播进行临床研究,从而为减少医院HLAR感染的发生提供分子生物学依据。

The high-level aminoglycoside- resistant （HLAR） enterococcus is an important pathogen for nosocomial infection, and amin- oglycoside modifying enzyme （ AME ） is key mechanism of high -level aminoglycoside resistance in enterococcus. N -acetyl transferase （AAC）, O-nucleoside transferase （ANT） and O-phosphorus transferase enzyme （APH） are main aminoglycoside modifying enzymes in- volved in the expression of resistance gene . Now to make clinical research on resistance genes and their transmission of aminoglycoside modifying enzyme, thus can provide the basis of the molecular biology for reducing nosocomial infections caused by HLAR .