眩痛停方对离体犬基底动脉收缩反应的影响

Effect of Xuantongting Recipe on the in vitro basilar artery in dogs

目的观察眩痛停方对犬离体基底动脉收缩反应的影响。方法分离犬基底动脉并置于血管环灌流装置中,基底动脉预先给予含药血清,记录去氧肾上腺素或高钾离子作用于犬基底动脉后的血管收缩反应。结果眩痛停方对血管平滑肌的张力性收缩具有较好的拮抗作用(与生理盐水组比,P<0.05),且随剂量的增加呈现出一定的量效关系;眩痛停方对血管平滑肌的相位性收缩没有抑制作用。结论眩痛停方降低麻醉犬脑血管阻力,增加脑血流量的机制可能与其抑制细胞外钙内流,抑制基底动脉血管收缩有关。

Objective To observe the effect of XTT recipe on the in vitro basilar artery in dogs. Methods We recorded the reactions of vasoconstriction of the isolated basilar artery in dogs placed in the perfusion device,which was preincubated with serum containing XTF recipe, followed by the incubation with phenylephrine （PHE） or high concentration of potassium ion. Results The antagonistic action of XTI＂ recipe on the tonic contraction caused by PHE could be observed obviously （ compared with NS groups, P 〈 0.05 ）, and the dose- effect relationship could be visual. But the inhibitory effects, of XTY recipe on the phasic contraction caused by high concentration of po- tassium ion could not be observed. Conclusions The pharmacological mechanisms of action that XTT recipe decrease the cerebral vascular resistance and increase the cerebral blood flow might be related to its blocking the entry of calcium ions into cells, followed by inhibiting the contraction of smooth muscle of basilar artery leading to vasodialatation.