2011年亳州市2182例药品不良反应/事件报告分析

Analysis of 2182 adverse drug reactions / events cases of Bozhou in 2011

目的探讨亳州市2011年药品不良反应/事件发生的特点及一般规律,为临床安全、有效、合理用药提供参考;评价药品不良反应/事件报告表填写质量。方法采用Excel电子表格筛选,按患者性别、年龄、药品种类、不良反应临床表现类型、给药途径等进行统计分析。结果≥60岁的中老年人不良反应/事件构成比高(29.29%),药品不良反应/事件涉及的药品以抗微生物药最多(59.88%),给药途径以静脉滴注用药所占比例最大(84.51%),不良反应/事件临床表现以皮肤及其附件的损害最常见(46.49%)。结论加强药品不良反应/事件监测工作,合理使用抗微生物药,确保临床安全、有效、合理用药。

Objective To investigate the characteristics adverse drug reaction/event in Bozhou in 2011 s, to provide reference for clinical safe, effective, rational use of drug, and to evaluate report quality of adverse drug reaction/incident. Methods Excel spreadsheet was a- dopted for screening and statistical analyies, according to sex and age of patients, drug adverse reactions, clinical manifestation, and route of administration. Results Among patients over 60 years and older adverse event rate was high （ 29.29% ）. Adverse drug reaction/event involving drugs were mainly anti mierobial medicine （59.88%）. The route of administration by intravenous drug use accounted for the largest proportion （84.51%）. The most common clinical manifestations were damages to skin and its appendages （46.49%）. Conclusions We should strengthen the adverse drug reaction/event monitoring work, make rational use of antimierobial agents, to ensure the clinical safe, effective, and rational drug use.