非洛地平缓释片治疗肾性高血压的临床疗效及对生活质量的影响

Felodipine zyban in treatment of renal hypertension and the influence on quality of life

目的探讨非洛地平缓释片治疗肾性高血压的临床疗效及对生活质量的影响,以期能为肾性高血压治疗药物的选择提供参考。方法肾性高血压患者60例,按照数字表格法随机分为观察组与对照组各30例,对照组服用福辛普利钠片10 mg/次,观察组服用非洛地平缓释片5 mg/次,每天1次,治疗8周后评价疗效,采用生活质量核心问卷-30(QLQC-30)调查患者生活质量。结果观察组治疗总有效率(93.33%)高于对照组(86.67%),但差异无统计学意义(P>0.05)。2组患者治疗后收缩压、舒张压、尿蛋白、血肌酐均较治疗前下降(P<0.05),观察组收缩压、舒张压较对照组下降更明显(P<0.05),对照组尿蛋白较观察组下降明显(P<0.05);观察组患者QLQC-30评分中躯体功能、角色功能、情绪功能、疲乏、疼痛、失眠及整体生活质量评分高于对照组(P<0.05)。观察组不良反应发生率(13.33%)低于对照组(20.00%),但差异无统计学意义(P>0.05)。结论非洛地平缓释片治疗肾性高血压降压效果肯定,用药安全,患者生活质量明显得到提高。

Objective To explore felodipine tablets in the treatment of renal hypertension clinical efficacy and impact on quality of life, provide reference for renal hypertension drug selection reference. Methods Sixty patients with renovascular hypertension, according to the digital form were randomly divided into observation group and control group with 30 patients. In the control group were treated with fosinopril sodium tablets 10 mg / times, the observation group taking felodipine tablets 5 mg/times a day, evaluated after 8 weeks of treatment, the use of the core quality of life questionnaire-30 （QLQC-30） investigated the quality of life of patients. Results The total effective observation group （93.33 % ） was higher （ 86.67% ）, but the difference was not statistically significant （ P 〉 0. 05 ）. Two groups of patients after treatment systolic blood pressure, diastolic blood pressure, urine protein, serum creatinine compared with before treatment （ P 〈 0.05 ）, the observation group systolic and diastolic pressure decreased more significantly than the control group （ P 〈 0.05 ）, control group＇s urinary protein decreased significandy compared with the observation group （ P 〈 0.05） ; obseivation group were QLQC 30 ratings in physical function, role function, emotional function, fatigue, pain, insomnia, and overall quality of life score higher （ P 〈 0.05）. The incidence of adverse reactions was observed （ 13.33% ） than the control group （20.00%）, but the difference was not statistically significant （ P 〉 0.05）. Conclusion Felodipine tablets in treating hypertension antihypertensive effect certainly, medication safety, patient quality of life was significantly improved.