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microRNA在HIV感染中的研究进展及应用前景

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摘要 微小RNA（microRNA，miRNA）是一种重要的转录后基因表达调节因子，在所有基因转录本中半数以上受到这一方式的精细调节。大多数成熟的miRNA长度为19～22个核苷酸，来源于基因组的非蛋白质编码区域，通过蛋白复合体与mRNA转录本的3’端非翻译区互补结合，
作者 张宏伟 张美 吴昊
机构地区 首都医科大学附属北京佑安医院感染中心
出处 《疑难病杂志》 CAS 2013年第12期972-974,978,共4页 Chinese Journal of Difficult and Complicated Cases
基金 2012年度丰台区卫生系统科研项目 艾滋病研究北京市重点实验室(BZ0089)
关键词 微小RNA 人免疫缺陷病毒 转录后调控
分类号 R512.91 [医药卫生—内科学]
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参考文献31

  • 1Friedman RC, Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs[ J]. Genome Res, 2009, 19 ( 1 ) : 92- 105.
  • 2Swaminathan S, Murray DD, Kelleher AD. The role of microRNAs in HIV-1 pathogenesis and therapy [ J]. AIDS, 2012, 26 ( 11 ) : 1325- 1334.
  • 3赵红梅(综述),于修平(审校),栾怡(审校).miRNA与病毒感染的研究进展[J].国际病毒学杂志,2008,15(1):12-16. 被引量：1
  • 4Swaminathan S, Murray DD, Kelleher AD. miRNAs and HIV : unfore- seen determinants of host-pathogen interaction [ J ]. Immunol Rev, 2013, 254(1 ): 265-280.
  • 5Gupta A, Nagilla P, Le HS, et al. Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Ceils In- fected with Human Immunodeficiency Virus ( HIV-1 ) [ J ]. PLoS ONE, 2011, 6(7): e22730.
  • 6Witwer KW, Watson AK, Blankson JN, et al. Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-l-infected elite suppressors and viremic patients [ J ]. Retrovirolo- gy, 2012, 9:5.
  • 7Sun G, Li H, Wu X, et al. Interplay between HIV-1 infection and host microRNAs [ J ]. Nucleic Acids Res, 2012, 40 ( 5 ) :2181-2196.
  • 8Huang J, Wang F, Argyris E, et al. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes [ J]. Nat Med, 2007, 13 (10) : 1241-1247. Triboulet R, Mari B, Lin YL, et al. Suppression of microRNAsileneing pathway by HIV-1 during virus replication [ J ]. Science, 2007, 315 (5818) :1579-1582.
  • 9Swaminathan S, Suzuki K, Seddiki N, et al. Differential Regulation of the Let-7 Family of MicroRNAs in CD4+ T Cells alters IL-10 Expression [J]. J Immunol, 2012, 118(12) : 6238-6246.
  • 10Seddiki N, Phetsouphanh C, Swaminathan S, et al. The microRNA-9/ B-lymphocyteinduced maturation protein-1/IL-2 axis is differentially reg- ulated in progressive HIV infection[ J]. Eur J Immunol, 2013,43 (2) : 510-520.

二级参考文献19

  • 1Nelson C. Lau, Lee P. Lim, Earl G. Weinstein, e tal. An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans. Science,2001, oct. 26 vol 294
  • 2Po Yu Chen, Heiko Manninga, Krasimir Slanchev, The developmental miRNAprofiles of zebrafish as determined by small RNA cloning . Genes & Dev, 2005 ,19:1288-1293
  • 3Venugopal Nair, Mihaela Zavolan Virus-encoded microRNAs: novel regulators of gene expression. Trends in Microbiology , 2006, 14 (4) :169-175
  • 4Eugene Berezikov, Edwin Cuppen & Ronald H A Plasterk. Approaches to microRNA discovery. Nature Genetics, 2006,38, S2 - S7
  • 5Catherine L. Jopling, MinKyung Yi. modulation of hepatitis c virus RNA abundance by a liver-specific microRNA, science, 2005,309 (5740) :1577-1581.
  • 6Chang-Zheng Chen. MieroRNAs Modulate Hematopoietic Lineage Differentiation Science, 2004, 303:83-86
  • 7Gupta A, Gartner JJ, Sethupathy P, etal. Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Nature, 2006,Jul 6;442(7098):82-5. Epub 2006 May 31
  • 8Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci, USA 2002 ; 99 : 15524-15529
  • 9Michael MZ, O' Connor SM, van Hoist Pellekaan NG, etal Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res,2003, 1 : 882-891
  • 10Takamizawa J, Konishl H, Yanagisawa K, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res, 2004,64: 3753-3756.
疑难病杂志
2013年 第12期

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