幽门螺杆菌感染与肺癌关系的Meta分析

THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI INFECTION AND LUNG CANCER:A META-ANALYSIS

目的探索幽门螺杆菌感染与肺癌之间的关系。方法在Pubmed、Embase、万方、维普、中国知网等数据库中进行文献检索，筛选研究幽门螺杆菌感染与肺癌之间关系的文献，提取数据并利用Meta分析进行定量综合分析，计算合并比值比及其95％可信区间（95％CI）。所有统计操作由Stata12．0软件进行。结果本次Meta分析共纳入8篇文献，共2153例研究对象，包括病例组1061例，对照组1092例。病例组与对照组中的幽门螺杆菌感染率存在显著差异，Meta分析显示合并比值比为1．15（95％CI：1．01～1．31），P=0．035。结论幽门螺杆菌感染与肺癌密切相关，可能是肺癌的重要致病因素。

Objective To explore the potential association of Helicobacter pylori （H. pylori） infection with lung cancer risk. Methods A literature search was conducted in Pubmed, Embase, WangFang, VIP data and CNKI to select the relevant publications on the association between H. pylori infection and lung cancer. Essential data were extracted from them included studies and further analyzed by a metaanalysis. The pooled odd ratio and its 95℃/were calculated. All the statistical analysis was finished by software Stata 12.0. Results A total of eight studies with 2153 subjects met the inclusion criteria and thus were finally selected, including 1061 cases and 1092 controls. The H. pylori infection rate was significant different between lung cancer patients and controls, the pooled odd ratio was 1.15（95 %CI 1.01-1.31）with a p value of 0. 035. Conclusion This result suggests H. pylori infection is associated with lung cancer, H. pylori may be a potential risk factor for lung cancer.