(Z)-7-苯亚甲基-5H-二苯并[b,g][1,4]氧氮杂环辛-6(7H)-酮的合成

Synthesis of (Z)-7-Benzylidene-5 H-dibenzo[b,g][1,4]oxazocin-6(7 H)-one

以2-碘苯酚和2-氟硝基苯为原料,经Ullmann缩合、还原、Sonogashira偶联、羰基环化反应首次合成了(Z)-7-苯亚甲基-5 H-二苯并[b,g][1,4]氧氮杂环辛-6(7 H)-酮,总收率34.9%。产物结构经1 H NMR、13C NMR和MS表征。

The new compound （Z）-7-benzylidene-5H-dibenzo[b, g][-1, 4-]oxazocin-6（7H）-one was synthe- sized through Ullmann etherification, reduction, Sonogashira coupling and intramolecular earbonylation reaction using 2-iodophenol and 1-fluoro-2-nitrobenzene as raw materials. The total yield was 34.9%. The Product structure was characterized by 1H NMR, 13C NMR and GC-MS.