摘要
研究了纯化的小花棘豆溶血毒素对培养的非洲罗猴胎肾细胞系细胞（ＭＡ－１０４）和绵羊胎肾细胞的影响，结果表明：毒素能抑制并杀死培养细胞；一定量的毒素（２ μｇ·ｍ ｌ－ １终浓度）能在３ ｈ 之内使正常细胞发生形态异变，线粒体标志酶显色结果及已有研究结果提示该毒素能够通过影响线粒体来毒害整个细胞。
In this paper a prelim inary study wasm ade on the effectofhem otoxin from Oxytropisglabra DCon theculturalcellsderived from MA-104 cells and baby sheep kidney. The result indicated thatthe toxin could inhibit the norm algrowth ofthe culturalcells and even m ightdestroy them .The toxin with ofthe culturalcells and even m ightdestroy them . The toxin with finalconcentration of2μg·m l- 1 could cause abnorm alchangesm orphologi- cally ofthecellswithin 3 hours.Itwassuggested oneofthe possibletoxicalm echanism ,by the resultofm ark-enzym e assay com bined w ith those related studies reported thatthe toxin m ay destroy cellsby attacking itsmitochondria first.
出处
《新疆农业大学学报》
CAS
1999年第3期185-188,共4页
Journal of Xinjiang Agricultural University
基金
国家863 计划
