磁弹性传感器检测芯片在凝血检测中的应用

Application of magnetoelastic transducer detection chip in blood coagulation detection

根据磁弹性传感器原理,设计了一种凝血检测芯片。芯片由铁基非晶合金和倒T型塑料底片构成,利用液体黏粘度对铁基非晶合金共振特性的影响实现对凝血过程的动态跟踪和凝血酶原时间的测定。实验结果表明:该检测芯片的幅值响应与凝血过程具有高度的相关性。重复测试3次,利用幅值斜率最大点确定的凝血酶原时间均值为13.7 s,而人工试管法的测量结果为13.1 s,表明该方法具有较高的准确性。此外,该芯片具有制作简单、成本低廉、体积小、测试用血量少等优点。

A chip for blood coagulation detection is designed based on the principle of magnetoelastic transducer. The chip is composed of Fe-based amorphous alloys and an inverted T-shaped plastic bottom film. The dynamic tracking of the blood clotting process and the determination of prothrombin time are achieved by using the influence of liquid viscosity changing on resonance characteristics of Fe-based amorphous alloy. Experimental results show that amplitude response of the detection chip has high degree of correlation with blood coagulation process. The mean value of prothrombin time in three tests is 13.7 s determined by the maximum point of the slope of the amplitude,the measurement result of the artificial tube method is 13.1 s, which indicates that this method has high accuracy. In addition, this kind of chip is easy to fabricate, low cost, small in size, and a very small quantity of blood is required for detected.