肠促胰素对骨代谢的作用

Effects of incretin on bone metabolism

近年来文献相继报道肠促胰素除对糖代谢产生作用外,在骨代谢方面也产生重要作用,主要表现在促进骨形成、抑制骨吸收.其机制尚不明确,可能是通过影响骨钙素基因表达、骨保护素/核因子-κB受体活化因子配体系统和骨硬化蛋白水平.此外,肠促胰素对晚期糖基化终末产物、胰岛素、胰岛素样生长因子、降钙素及血脂的作用也可能影响骨代谢.

Literatures have been reported in recent years that incretin plays an important role in bone metabolism,mainly in promoting bone formation and inhibiting bone resorption,in addition to its effects on glucose metabolism.The mechanism is not clear,may be by affecting the expression of osteocalcin,osteoprotegerin/receptor activator of nuclear factor kappa-B ligand system and level of sclerosin.In addition,the action of incretin on advanced glycation end products,insulin,insulin-like growth factor,calcitonin and blood lipids may also affect bone metabolism.