期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肝癌缺失基因1与原发性肝癌的研究进展 被引量：2

Research development of DLC-1 gene in hepatocellular carcinoma
原文传递
导出
摘要 肝癌缺失基因-1(DLC-1)是从原发性肝癌组织中分离出来的一种肿瘤抑制基因。它在人类多种恶性肿瘤中表达缺失或下调,是近年来研究比较热门的肿瘤抑制基因之一。本文将对DLC-1基因的结构及生物学功能作一介绍,结合目前关于DLC-1在肝癌中的最新研究成果,探讨DLC-1基因在肝癌发生发展中的作用机制,并对DLC-1在肝癌中表达缺失的遗传学和表观遗传学机制进行了深入讨论。 Deleted in liver cancer I（DLC-I）, a tumor suppressor gene, is separated from primary liver cancer tissue. Its expression is down-regulated or absent in a variety of human malignant tumors and also a tumor suppressor gene hot in recent researches. This article will firstly introduce the structure and biological function of the DLC-1 gene, and then discuss the mechanism of the DLC-1 gene in the development of liver cancer, combined with the latest research achievements at present about DLC-1 in hepatocellular carcinoma. The last part is more in-depth discussions of the DLC-1 expression in HCC missing genetics and epigenetic mechanisms.
作者 彭鹏 胡泽民
机构地区 广东医学院 中山市人民医院肝胆外科
出处 《中华普通外科学文献（电子版）》 2013年第5期51-54,共4页 Chinese Archives of General Surgery(Electronic Edition)
关键词 肝癌缺失基因1 肝癌 肿瘤抑制基因 DLC-1 Hepatocellular carcinoma Tumor suppressor gene
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献30

  • 1Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol, 2009, 27(9): 1485-1491.
  • 2Yuan BZ, Miller MJ, Keck CL, et al. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-l) homologous to rat RhoGAP. Cancer Res, 1998,58(10): 2196-2199.
  • 3Ko FC, Yeung YS, Wong CM, et al. Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma. Liver Int, 2010,30(1): 139-148.
  • 4Low JS, Tao Q, Ng KM, et al. A novel isoform of the 8p22 tumor suppressor gene DLCI suppresses tumor growth and is frequently silenced in multiple common tumors. Oncogene, 2011, 30(16): 1923-1935.
  • 5Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Bioi, 2008,9(9): 690-701.
  • 6Grise F, Bidaud A, Moreau V. Moreau, Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta, 2009, 1795(2): 137-151.
  • 7Qiao F, Bowie JU. The many faces of SAM. Sci STKE, 2005, 2005(286): re7.
  • 8Kim TY, Healy KD, Der CJ, et al. Effects of structure of Rho GTPase-activating protein DLC-l on cell morphology and migration. J Bioi Chern, 2008, 283(47): 32762-32770.
  • 9Zhong D, Zhang J, Yang S, et al. The SAM domain of the RhoGAP DLCI binds EFIAI to regulate cell migration. J Cell Sci, 2009, 122(Pt 3): 414-424.
  • 10Strauss JF 3rd, Kishida T, Christenson LK, et al. START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells. Mol Cell Endocrinol, 2003, 202(1-2): 59-65.

二级参考文献13

  • 1Kamangar F, Dores GM, Anderson WF. Pattents of cancer incidence, mortality,and prevalence across five continents:defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Onco1,2006,24- :2137-2150.
  • 2Berthold J ,Schenkov6 K, Ramos S ,et al. Characterization of RhoBTB- dependent Cul3 ubiquitin ligase complexes-Evidence for an autoregu-latory mechanism. Exp Cell Res,2008,314 : 3453-3465.
  • 3Kim JE, Chen J, Lou Z. p30 DBC is a potential reglator of tumorigen- esis. Cell Cycle,2009,8:2932-2935.
  • 4Hill VK, Hesson LB, Dansranjavin T, et al. Identification of 5 novel genes methylated in breast and other epithelial cancers. Mol Cancer, 2010,9:51.
  • 5Hamaguchi M, Meth JL, von Klitzing C, et al. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc Natl Aead Sei U S A ,2002,99 : 13647-13652.
  • 6Fu J,Jiang J,Li J,et al. Deleted in breaat cancer I ,a novel androgen receptor ( AR ) coactivator that promotes AR DNA-binding activity. J Biol Chem,2009,284:6832-6840.
  • 7Kim JE, Chen J, Lou Z. DBC1 is a negative gulator of SIRT1. Na- ture ,2008,451:583-586.
  • 8Kh HB ,Zhang R, Verdoodt B, et 81. Large-ale identification of e,-MYC-associated proteins using a cmnbined TAP/MudPIT approach. Cell Cycle ,2007,6:205-217.
  • 9Sundararajan R,Chen G, Mukherjee C, et al. Caspase-dependent pro- cessing activates the proapoptotie activity of deleted in breast cancer-1 during tumor necrosis factor alpha mediated death signaling. Oneo- gene,2005,24:4908-4920.
  • 10Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell ,2011,144:646-674.

共引文献1

同被引文献31

  • 1董玖红,文建凡.小分子GTP酶的结构与功能[J].生命的化学,2005,25(5):422-424. 被引量：4
  • 2姜凤元,陈晓泉.肝细胞癌组织C-met的表达与临床意义[J].陕西医学杂志,2007,36(3):307-309. 被引量：2
  • 3阴棉棉.小鼠卵泡发育过程中MiRNA-383和MiRNA-320的功能研究[D].安徽:中国科技大学,2013.
  • 4秦荣,蒲永东,杨波,何建苗,董立国,曹志宇,何振平.c-Met及HGF在胃癌及其肝转移灶中的表达[J].西南国防医药,2007,17(6):715-717. 被引量：4
  • 5XUE W, KRASNITZ A,LUCIT0 R,et al. DLC1 is a chromosome8p tumor suppressor whose loss promotes hepatocellular carcinoma[J]. Genes Dev,2008,22(11) : 1439 -1444.
  • 6YIN M, LV M,YAO G, et al. Transactivation of microRNA - 383by steroidogenic factor - 1 promotes estradiol release from mouse o-varian granulosa cells by targeting RBMS1 [ J ]. Mol Endocrinol,2012,26(7):1129 -1143.
  • 7ZHOU X L,ZIMONJIC DB,PARK S W,et al. DLC1 suppresses dis-tant dissemination of human hepatocellular carcinoma cells in nudemice through reduction of RhoA GTPase activity, actin cytoskeletaldisruption and down - regulation of genes involved in metastasis[ J].Int J Oncol,2008,32(6) : 1285 -1291.
  • 8WU P P,JIN Y L,SHANG Y F, et al. Restoration of DLC1 gene in-hibits proliferation and migration of human colon cancer HT29 cells[J]. Ann Clin Lab Sci,2009,39(3) ;263 -269.
  • 9DURKIN M E,ULLMANNOVA V,GUAN M,et al. Deleted inlivercancer 3 (DLC - 3 ),a novel Rho GTPase - activating protein,isdownregulated in cancer and inhibits tumor cell growth [ J ]. Onco-gene,2007,26(31) :4580 -4589.
  • 10黄小兵,李靖,梁平,郑璐,刘世呈,韩克强.BC047440基因RNA干扰抑制肝癌HepG2细胞增殖[J].中华消化外科杂志,2008,7(3):196-199. 被引量：5

引证文献2

二级引证文献3

中华普通外科学文献（电子版）
2013年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部