鱼腥草中生物碱和酰胺类成分的研究

Alkaloids and amides from Houttuynia cordata

目的研究鱼腥草（Houttuyniacordata）的化学成分。方法采用大孔树脂AB-8柱色谱、硅胶柱色谱、SephadexLH-20柱色谱、反相I-IPLC等手段从鱼腥草的体积分数50％乙醇提取物中分离得到11个化合物，利用波谱学方法鉴定其化学结构。结果分离得到的11个化合物，分别鉴定为cepharanoneB（1）、胡椒内酰胺A（piperolactamA，2）、马兜铃内酰胺AII（aristololactamAII，3）、4．5-dioxodehy，droasimilobine（4）、缺碳金钱吊乌龟二酮B（norcepharadioneB，5）、cepharadioneB（6）、橙黄胡椒酰胺苯甲酸酯（aurantiamidebenzoate，7）、橙黄胡椒酰胺乙酸酯（aurantiamideacetate，8）、卅反式阿魏酸酰酪胺（N-transferuloyltyramine，9）、橙黄胡椒酰胺（aurantiamide，10）和N-苯乙基苯甲酰胺（N-phenethylbenzamide，11）。结论化合物7-10为首次从三白草科植物中分离得到。

Objective To study chemical constituents of Houttuynia cordata. Methods Eleven compounds were isolated and purified from the 50% aq. EtOH of the extract of H. cordata by macroporous resin AB-8, silica gel, Sephadex LH-20 column chromatography and preparative HPLC, and their structures were deter- mined based on spectroscopic methods. Results All the obtained compounds were identified as cepharanone B （ 1 ）, piperolactam A （ 2 ）, aristololactam AII（ 3 ）, 4,5-dioxodehydroasimilobine （ 4 ）, norcepharadione B （5）, cepharadione B （ 6 ）, aurantiamide benzoate （ 7 ）, aurantiamide acetate （ 8 ）, N-transferuloyltyramine （9）, aurantiamide （10） ,N-phenethylbenzamide （11）. Conclusion Compounds 7-10 are obtained from the Saururaceae family for the first time.