摘要
High intensity focused ultrasound(HIFU)therapy is an effective method in clinical treatment of tumors,in order to explore the bio-heat conduction mechanism of in multi-layer media by concave spherical transducer,temperature field induced by this kind of transducer in multi-layer media will be simulated through solving Pennes equation with finite difference method,and the influence of initial sound pressure,absorption coefficient,and thickness of different layers of biological tissue as well as thermal conductivity parameter on sound focus and temperature distribution will be analyzed,respectively.The results show that the temperature in focus area increases faster while the initial sound pressure and thermal conductivity increase.The absorption coefficient is smaller,the ultrasound intensity in the focus area is bigger,and the size of the focus area is increasing.When the thicknesses of different layers of tissue change,the focus position changes slightly,but the sound intensity of the focus area will change obviously.The temperature in focus area will rise quickly before reaching a threshold,and then the temperature will keep in the threshold range.
High intensity focused ultrasound （HIFU） therapy is an effective method in clinical treatment of tumors, in order to explore the bio-heat conduction mechanism of in multi-layer media by concave spherical transducer, temperature field induced by this kind of transducer in multi-layer media will be simulated through solving Pennes equation with finite difference method, and the influence of initial sound pressure, absorption coefficient, and thickness of different layers of biological tissue as well as thermal conductivity parameter on sound focus and temperature distribution will be analyzed, respectively. The results show that the temperature in focus area increases faster while the initial sound pressure and thermal conductivity increase. The absorption coefficient is smaller, the ultrasound intensity in the focus area is bigger, and the size of the focus area is increasing. When the thicknesses of different layers of tissue change, the focus position changes slightly, but the sound intensity of the focus area will change obviously. The temperature in focus area will rise quickly before reaching a threshold, and then the temperature will keep in the threshold range.
基金
Project(11174077)supported by the National Natural Science Foundation of China
Project(11JJ3079)supported by the Hunan Provincial Natural Science Foundation of China
Projects(12C0237,11C0844)supported by the Science Research Program of Education Department of Hunan Province,China
