间歇雾化吸入联合振动排痰机治疗COPD患者的效果观察

Effect of Intermittent Atomization with Vibration Expectoration Machine on Patients with Chronic Obstructive Pulmonary Disease

目的观察间歇氧气雾化吸入联合振动排痰机治疗慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者的排痰效果。方法将呼吸内科收治的COPD患者随机分为观察组50例和对照组50例，两组患者均进行常规治疗，观察组采用间歇雾化吸入联合振动排痰机治疗，每次雾化吸入5—7min后间歇10min，间歇期予低流量吸氧并使用振动排痰机排痰，每次雾化间歇2次；对照组采用传统持续雾化吸入联合振动排痰机治疗，比较两组的排痰效果、雾化吸入完成情况和不良反应。结果观察组在雾化吸入第1、第3、第5天的日排痰量较对照组多，未完成雾化治疗例数、雾化吸入过程中发生的不良反应较对照组少，差异均有统计学意义（P〈0．05或P〈0．01）。结论间歇雾化吸入联合振动排痰机治疗COPD排痰效果好，患者耐受性好，不良反应较少，值得临床推广应用。

Objective To observe the effect of intermittent atomization with vibration expectoration machine on patients with chronic obstructive pulmonary disease （COPD）. Methods One hundred patients with COPD were randomly divided into observation group and control group, with 50 cases in each group. Besides routine drug treatment,the intermittent atomization combined with vibration expectoration machine was applied in observation group, but persistent atomization combined with vibration expectoration machine in control group. The effect of sputum elimination and side effects were compared between two groups. Results There were more sputum eliminated in observation group than that in control group on the first, third and the fifth day after atomization and less side effects. The difference of sputum and side effects were statistically significant between two groups （P〈0.05）. Conclusion The intermittent atomization combined with vibration expectoration machine is effective for eliminating sputum and reducing side effects thus patients are with good tolerance.