吲哚菁绿在影像医学中的应用

Review of indocyanine green in medical imaging applications

吲哚菁绿（ICG）是一种在近红外光谱范围内有较强吸收、毒性小、不参与体内生物转化、排泄迅速的荧光染料，是目前惟一被美国食品药品管理局（FDA）批准的，临床使用的近红外光学成像对比增强剂。由于近红外光学成像因近红外光在生物组织中具有更强的穿透能力，而且受其他因素影响较小，所以被广泛应用于功能成像和异常组织诊断的研究，在组织光学检测方面具有较大的发展前景。因此，ICG在生物医学成像、光动力治疗及病理组织检测等领域的应用持续升温。重点从临床应用角度综述了ICG在影像医学中的应用。

Indocyanine green （ICG） is a fluorescent dye which has various advantages including high absorption, low toxicity, not involved in biotransformation in vivo and rapid excretion in near-infrared range. Due to the high penetrating ability in biological tissues and low rate of being affected by other factors, near-infrared optical imaging has become a major method of functional imaging and diagnosis. It shows great prospects in optical detection. As the only clinical using near-infrared optical imaging contrast enhancer approved by FDA, ICG has been widely used in biomedical imaging, photodynamic therapy, pathology detection and many other medical related areas. This article focuses on the recent development of ICG application, especially concentrates on the clinical uses.