胚胎干细胞致瘤性研究进展

Research progress in the tumorigenicity of embryonic stem cells

干细胞（SCs）研究是目前生命科学和医学领域研究的热点。SCs可分为胚胎干细胞（ESCs）和成体干细胞。ESCs来源于胚胎囊胚时期的内细胞团，具有分化的全能性和无限增殖能力，在组织工程、基因治疗和发育生物学基础研究等领域中具有广泛的应用前景；但同时因致瘤性等问题未得到解决，而限制了其发展。就国内外普遍认可的ESCs致瘤性的原因及解决方法进行综述，为ESCs应用过程中致瘤性问题的解决提供参考。

Stem cells research is the hotspot in the field of biological science and medicine. Stem cells can be classified into embryonic stem cells and somatic stem ceils. Embryonic stem cells derived from early pre- implantation embryo have the pluripotent and unlimited self-renewal capacity. They are an attractive source for tissue engineering, gene therapy, basic study of developmental biology and so on. However, such therapies carry a risk of teratoma formation, and may contribute to the functional failure of the graft. Here, we discuss the reasons for the formation of teratoma and the solutions to this problem.