痔速宁对Ⅱ度内痔急性期的疗效

Effect of Zhisuning tablets on the prognosis of patients with Ⅱ internal hemorrhoids

目的观察痔速宁对Ⅱ度内痔急性期疗效及其预后的影响。方法Ⅱ度内痔患者随机分为2组:2组均给予马应龙痔疮栓治疗,试验组同时加用痔速宁片(4片/次,每天3次;疗程为2周)。随访半年,比较2组临床疗效、症状评分、预后及药物不良反应的差别。结果试验组总有效率显著高于对照组(87.31%vs 77.61%)(P<0.05);治疗后1,2周后,试验组疼痛、便血及瘙痒评分均显著低于对照组(P<0.05)。试验组和对照组复发率(20.51%vs 34.62%)、复发>3次(6.84%vs 16.35%)及发展至Ⅲ或Ⅳ度比例(4.27%vs 11.54%)比较,差异有统计学意义(P<0.05)。试验组药物不良反应发生率(7.46%)略高于对照组(2.99%),但差异无有统计学意义(P>0.05)。结论痔速宁片可提高Ⅱ度内痔急性期疗效、改善症状、降低复发或进展,且安全性较好。

Objective To study the effect of Zhisuning tablets on the patients with Ⅱ internal hemorrhoids. Methods Two hundreds and sixty- eight cases were randomly divided into two groups： the patients in control group （n = 134） were given Mayinglong hemorrhoids suppository 0.33 g every time, twice a day for 2 weeks. On this basis, the patients in trial group were given Zhisuning tablets 0.8 g every time, twice a day for 2 weeks as well. The patients followed - up for half a year. The total effective rate, scores of pain, prognosis , and adverse drugs reaction in two groups were investigated. Results The total effective rate in the trial group was significantly higher than that in the control group （87.31% vs 77.61% ） （P 〈0. 05）. After 1^st and 2^nd treatment, the scores of pain, hematochezia and itching in the trial group were significantly lower than that in the control group（P 〈0. 05）. There＇s significant difference in recurrence rate（20. 51% vs 34. 62% ）, the ratio of recurrence times 〉 3 （6. 84% vs 16.35% ） and the ratio of development to Ⅲor Ⅳdegree hemorrhoids （4. 27% vs 11.54% ）between the two groups （P 〈 0. 05 ）. There＇s no significant difference in adverse drugs reactions between the two groups （7.46% vs 2.99% ） （P 〉 0. 05 ） Conclusion Zhisuning tablets had a good effect on the patients with internal hemorrhoids.