不同原料生产赖氨酸的研究进展

Research progress on lysine production using different carbon sources

赖氨酸是人类和动物的必须氨基酸之一,主要用作饲料添加剂,是目前应用量最大的氨基酸类添加剂。赖氨酸主要由发酵法生产,原料成本是影响整个生产过程的关键,对现有原料代谢进行优化,使更多的碳源流向赖氨酸的合成,以及对新原料的开发是当今提高赖氨酸发酵水平和降低成本的研究热点。文中以谷氨酸棒杆菌为例,对各种底物原料的转运代谢和目前比较关注的改进方向进行了阐述。

The essential amino acid L-lysine is one of the most important amino acids applied as supplement in animal feed. As we know, lysine is mainly produced by fermentation process, and raw material cost is the major factor for lysine production. To increase carbon efficiency, more studies are being done either on optimizing the synthesis pathways using existing industrial carbon sources or exploring new carbon sources. In this review, we provide an over- view of the metabolic pathways for utilization of different carbon sources, as well as new approaches of metabolic engi- neering on Corynebaeterium glutamicum.