葛根-丹参组方配伍对动脉粥样硬化鹌鹑脂质代谢的影响

Effects of combination of Puerariae Lobatae Radix and Salviae Miltiorrhizae Radix et Rhizoma on lipid metabolism in atherosclerotic quails

采用外源性胆固醇和高脂饲料建立鹌鹑动脉粥样硬化（As）模型，观察葛根-丹参（1：1）组方配伍对模型动物脂质代谢、肝脏系数及载脂蛋白Apo．A1，ApoB指标等的影响。结果葛根一丹参组方配伍水提物在7．5g·kg。和葛根一丹参组方配伍乙酸乙酯部位在2．5～7．5g·kg。剂量下，能明显或部分降低AS模型鹌鹑血清1℃，TG，LDL-C和VLDL—C的含量，升高HDL-C的含量；降低鹌鹑的肝脏质量和肝脏系数及模型动物ApoB的含量，升高ApoAl的含量，纠正Apo—A1／ApoB的异常，表明葛根一丹参组方配伍能明显调节脂质代谢的紊乱，该作用可能是葛根一丹参组方配伍抗动脉粥样硬化发生发展的药理学基础。

In present study, cholesterol/high fat diet-induced atherosclerotic quails were used to evaluate the effects of combi- nation of Puerariae Lobatae Radix and Salviae Miltiorrhizae Radix et Rhizoma （ 1 ： 1, abbreviated as PRSM） on lipid metabolism, liver index, apolipoproteiu levels. The results obtained from this study indicated that oral administration of ethyl acetate extract of PRSM at doses of 7.5, 5. 0, 2. 5 g· kg 1 as well as aqueous extract of PRSM at dose of 7.5 g ·kg-1 could reduce the serum cholesterol （TC）, triglycerides （TG）, low density lipoprotein cholesterol （LDL-C） and very low density lipoprotein cholesterol （VLDL-C） levels as well as the weight of liver and liver index, and increase the serum level of high density lipoprotein cholesterol （HDL-C）. Furthermore, re- duced levels of apolipoprotein B （ApoB） and elevated levels of apolipoprotein A1 （ApoA1） were observed in ethyl acetate extract and aqueous extract of PRSM treated atherosclerotic quails. All results demonstrate that PRSM possess a regulatory role on lipid metabolism disorders in atheroselerotie quails, which may be the pharmacological basis of PRSM for preventing the development of atherosclerosis.