红景天、蛹虫草、大黄配伍治疗代谢综合征的实验研究Ⅵ——对糖尿病大鼠肾脏保护作用

Investigation of compound,compatibility of Rhodiola crenulata,Cordyceps militaris,and Rhum palmatum,on metabolic syndrome treatment Ⅵ——improving hyperglycemia-mediated renal damage

探讨红景天、蛹虫草、大黄配伍(中药复方FF)对1型糖尿病大鼠肾脏的保护作用。采用链脲佐菌素诱导SD大鼠形成1型糖尿病模型,按禁食血糖水平随机分为模型对照组(Model)、胰岛素组(insulin)和FF治疗组。动态监测动物血糖、血脂水平和肾功能变化;10周后检测氧化应激水平。结果显示,连续给予中药复方FF能够明显降低1型糖尿病大鼠血糖、血脂水平;降低肾脏指数,降低血尿素氮水平、增加尿肌酐排出,降低尿酶活性和尿蛋白水平;使血清和肾脏中SOD活性升高、MDA含量降低。说明中药复方FF对1型糖尿病大鼠肾脏具有一定的保护作用,其机制可能与其降糖调脂、改善机体微循环及氧化应激水平等作用有关。

This study is to investigate the effects of a Chinese prescription （FF）, compatibility of Rhodiola crenulata, Cordyceps militaris and Rheum pal matum, on nephropathy in type 1 diabetic rats induced by streptozocin. According to fasting blood glucose level, diabetic rats were divided into three groups： model group, insulin-treated group and FF-treated group. Parameters for evaluating the glucose ＆ lipid metabolism and the renal function were monitored dynamically. Levels of oxidative stress were detected ten weeks later. The results show that FF could significantly decrease the level of serum glucose and lipid profiles, improve the renal functions by decreasing blood urea nitrogen, urine albumin excretion and urease activity; FF could also affect on oxidative stress. In conclusion, Chinese prescription FF could ameliorate hyperglycemia-mediated renal damage in type 1 diabetic rats. These effects may be related to its regulation on the metabolism of glucose and lipid, the microcirculation disturbance and the oxidative stress.