摘要
以自制的琥珀酰化壳聚糖(SUCS)和羟甲基-5-氟尿嘧啶(5-FuOH)为原料,制备了壳聚糖偶联载药体(SUCS-5-FuOH)。傅里叶红外光谱(FT-IR)、核磁共振(1H-NMR)、热重(TG)和X粉末衍射(XRD)等技术表征了产物的化学结构、热稳定性和结晶行为。并通过紫外光谱(UV)分析了产物对5-FuOH的接枝率及其体外释药行为。结果表明,SUCS和5-FuOH间通过酯键化学键合,接枝率(载药率)为18.7%,在模拟体液和酶存在条件下均有良好的缓释性能。
Chitosan coupling drug-loading body （SUCS-S-FuOH） was prepared with homemade succinyl chi tosan （SUCS） and hydroxymethyl-5-fluorouracil （5 Fu（）H） as materials. The chemical structure, thermal sta- bility and crystallization behavior of the obtained sample were characterized by Fourier infrared spectrum （FT IR）, nuclear magnetic resonance （＇H NMR）, thermal gravimetric analysis （TC-） and X-ray powder diffraction （XRD）. The grafting rate of 5 FuOH and the in vitro releasing performance were analysed by UV spectrum （UV）. The results indicated that SUCS and 5-FuOH were chemically bonded through ester linkage, the graft ing rate （drug loading rate） of SUCS-5-FuOH was 18.7%, and it had good sustained release performance under the condition of simulated body fluids and enzymes.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2013年第22期3239-3242,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目(51008243
51178378
51278408)
陕西省科技统筹创新工程计划资助项目(2012KTCL03-06)
陕西省榆林市科技资助项目(2011)
西安市碑林区科技资助项目(GX1105)
关键词
琥珀酰化壳聚糖
5-氟尿嘧啶
偶联药物
缓释
succinyl-chitosan
5-fluorouracil
drug-polymer conjugates
sustained release
