等离子体类聚氧乙烯薄膜的制备及性能研究

Fabrication and properties of plasma polyethylene oxide

等离子体类聚氧乙烯薄膜(PEO-like)具有高亲水性、抗生物粘附的特性,能被应用于生物材料表面改性以提高材料的抗蛋白粘附、抗血小板粘附和抗菌等性能。以四乙二醇二甲醚(tetraethylene glycol dimethyl ether)为单体,采用射频等离子体连续放电模式,不锈钢SS为基底,在不同功率下合成了PEO-like薄膜。傅里叶变换红外光谱仪(FT-IR)、X光电子能谱仪(XPS)测试分析表明等离子体PEO-like薄膜中能部分保留单体分子中的氧化乙烯(EO)结构单元,功率为5W合成的PEO-like薄膜中EO单元含量为35.86%。PEO-like薄膜的亲水性优于不锈钢,薄膜在双蒸水中浸没1和10d的结果显示,尽管薄膜出现溶胀现象,但没有剥落和破裂。低功率下合成的薄膜具有一定的阻抗血小板粘附的性能,但3d的体外平滑肌细胞评价结果表明,3种PEO-like薄膜没有表现出抑制平滑肌细胞增殖的性能。

The polyethylene oxide like （PEO-like）film prepared by plasma polymerization has high hydrophilici-ty and anti-bioadhesion,which can be used to modify the biomaterial surface to improve the inhibition of protein adhesion,platelet adhesion and anti-bacterial adhesion.The PEO-like films on stainless steel （SS）substrates were prepared by radio frequency plasma polymerization technique with tetraethylene glycol dimethyl ether （EGDME）as the precursor.The results of Fourier transform infrared spectroscopy （FT-IR）and X-ray photoe-lectron spectroscopy （XPS）showed that the PEO-like film could keep part of ethylene oxide unit,and especial-ly the EO content of PP-PEO-1 film fabricated under 5W power was 35.86%.Compared to the SS,there was more hydrophilic for the PEO-like films.The PEO-like films exhibited the swollen stripes,but the spalling and rupture could not be found.The PEO-like film prepared under 5W and 10W had certain properties to prohibit the adhesion of platelet.But the evaluation of in vitro smooth muscle cell （SMC）cultured for 3 days indicated that three kinds of PEO-like films had not shown the significant prohibition of SMC.