阿托伐他汀钙治疗老年冠心病合并高脂血症的疗效观察

Clinical effect of atorvastatin calcium in the treatment of elder patients with coronary heart disease complicated with hyperlipidemia

目的观察阿托伐他汀钙对高脂血症的疗效和安全性。方法将68例高脂血症合并冠心病的老年患者随机均分为观察组和对照组,观察组给予阿托伐他汀钙10mg,对照组给予辛伐他汀10mg,1d1次,疗程均为8周,检测并分析患者治疗前后血脂变化、不良反应发生情况和肝功、肌酸激酶水平。结果治疗8周后,观察组总胆固醇(TC)、低密度脂蛋白(LDL-C)和三酰甘油(TG)明显下降,高密度脂蛋白(HDL-C)轻度升高;观察组与对照组差异有统计学意义(P<0.05)。结论阿托伐他汀能显著降低老年冠心病患者的血脂水平,治疗高脂血症安全有效。

Objective To explore the effect and safety of atorvastatin calcium in the patients with coronary heart disease complicated with hyperlipidemia .Methods 68 patients with coronary heart disease complicated with hyperlipidemia were randomly divided in-to simvastatin control group and atorvastatin calcium intervention group .The intervention group was taken atorvastatin calcium 10 mg · d-1 for 8 weeks ,and the control group was taken simvastatin 10 mg · d-1 at the same time .After 8 weeks treatment ,the lev-els of lipid ,liver function ,creatine kinase and other adverse reactions of the two groups were observed .Result The levels of serum TC ,LDL-C and TG in intervention group were decreased significantly ,and the level of HDL-C was higher（P〈0 .05） .The attacks number of heart failure and angina pectoris increased .Conclusion Atorvastatin calcium can decrease the lipid levels in elderly pa-tients with coronary artery disease ,and it is safe and effective for the hyperlipemia treatment .