聚氯乙烯和超低密度聚乙烯延长管对盐酸多巴胺的吸附作用研究

Study on Absorbability of PVC and ULDPE Extension Sets to Dopamine Hydrochloride

目的:研究聚氯乙烯(PVC)和超低密度聚乙烯(ULDPE)延长管对盐酸多巴胺的吸附作用,为临床输液器材选择提供参考。方法:将盐酸多巴胺配制成临床用输注浓度,经2个不同厂家的一次性PVC延长管(PVC1、PVC2)和某一厂家的一次性ULDPE延长管微量泵出,收集0、2、4、8、12、24 h时的流出液,采用高效液相色谱法测定其峰面积,用外标法计算盐酸多巴胺浓度,并与0 h比较,计算吸附率。结果:PVC1、PVC2、ULDPE 3种延长管对盐酸多巴胺的吸附率分别为1.28%、-1.04%、-1.02%,3种延长管的吸附作用相比较差异无统计学意义(P>0.05)。结论:PVC和ULDPE延长管对盐酸多巴胺均无吸附作用。

OBJECTIVE： To study the absorbability of polyvinyl chloride （PVC） extension set and ultra low density polyethyl- ene （ULDPE） extension set to dopamine hydrochloride, and to provide reference for clinical choice of infusion sets. METHODS： Dopamine hydrochloride was prepared into suitable concentrations for injection, and flowed through PVC extension sets （PVC1, PVC2） from 2 different manufacturers and disposable ULDPE extension set from a manufacturer. The effluent liquid was collected at 0, 2, 4, 8, 12 and 24 h. The peak area of effluent liquid was determined by HPLC, and the concentrations of dopamine hydro- chloride were calculated by external standard and compared with that at 0 h. The adsorption rate was calculated. RESULTS： The ad- sorption rates of 3 kinds of extension sets PVC1 ~ PVC2, ULDPE were 1.28%, -1.04% and -1.02%; there was no statistical sig- nificance （P〉0.05）. CONCLUSIONS： PVC and ULDPE extension sets have no absorbability on dopamine hydrochloride.