三叶青藤抗炎活性部位研究

Study on the Anti- inflammatory active fraction of Illigera rhodantha Hance.

目的筛选三叶青藤的抗炎活性部位。方法分步溶剂萃取法制备不同极性部位,采用醋酸致小鼠腹腔毛细血管通透性模型、大鼠棉球肉芽肿模型筛选抗炎活性部位。结果三叶青藤正丁醇提取部位和水溶液部位能显著抑制小鼠腹腔毛细血管通透性增高以及大鼠棉球肉芽肿的形成。结论正丁醇提取部位和水溶液部位为三叶青藤的抗炎有效部位。

Objective To screen the active fraction with anti - inflammatory effect of Illigera rhodantha Hance. Methods Different polar fractions were prepared by extraction with organic solvents. Their anti - inflammatory effects were evaluated by acetic acid - induced celiac capillary permeability in mice and cotton pellets - induced granuloma in rats. Results N - butanol extracted fraction and water solution fraction of Illigera rhodantha Hance. could significantly inhibit the increasing of celiac capillary permeability and the cotton pellets granuloma. Conclusion The n - butanol extracted fraction and water solution fraction were effective anti - inflammatory fractions of Illigera rhodantha Hanee..