肠道微生物群落与炎症性肠病关系研究进展

The intestinal microbiota and inflammatory bowel disease

目的炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),以持续性肠道非特异性炎症为特征,通常反复发作、迁延不愈,临床上仍无特效性的治疗手段。IBD确切的发病机制尚不清楚,涉及免疫、环境及遗传等因素,这些因素共同诱导肠道炎症、黏膜损伤和修复。肠道微生物群落及其代谢产物、宿主基因易感性及肠道黏膜免疫三方面共同参与了IBD的发病机制。本文从消化道微生态角度出发,对目前IBD相关的肠道微生物群落研究现状、宿主-微生物间免疫应答及益生菌治疗等内容进行探讨。

Objective Inflammatory bowel disease （IBD） , including both ulcerative colitis （ UC ） and Crohn＇ s disease （CD） , which is a chronic relapsing nonspecific inflammatory disorder of the gastrointestinal tract. The etiology of IBD is unknown, the gut microbiota may play an important role. Altered or pathogenic microbiota and microbial metabolites, host genetically susceptibility, and the host innate and acquired immunity contribute to the pathogenesis of IBD. This paper reviewed the present researches of the association between the intestinal microbiota and IBD, the immune interactions between host and microbes, and the probiotics treatment of IBD.