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血清nectin-4、CA15-3、CEA联合检测在乳腺癌诊断中的价值 被引量：5

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摘要 目的探讨血清nectin-4、CA15-3、CEA在乳腺癌诊断中的应用价值。方法收集62例乳腺癌患者、59例乳腺良性疾病患者及30例体检健康者的临床样本,用ELISA法检测血清nectin-4的表达水平,用电化学发光免疫分析法检测血清CA15-3、CEA的表达水平。结果乳腺癌组血清nectin-4、CA15-3浓度均显著高于乳腺良性疾病组(P均<0.05);单项指标检测时血清nectin-4的Youden指数最高(0.452),其敏感性和特异性分别为77.4%和67.8%;nectin-4/CA15-3/CEA联合检测对乳腺癌诊断的敏感性、特异性和Youden指数分别为77.4%、69.5%和0.469,均高于单独检测指标。结论血清nectin-4/CA15-3/CEA联合检测比单一指标能提高乳腺癌的检测效能。
作者 姜肖刚 谢玮 陈相 李晗 曹兴建 陶国华
机构地区 南通市第一人民医院检验科
出处 《临床检验杂志》 CAS CSCD 北大核心 2013年第10期755-756,共2页 Chinese Journal of Clinical Laboratory Science
基金 江苏省南通市科技指导项目(S11962)
关键词 乳腺癌 nectin-4 糖类抗原15—3 癌胚抗原
分类号 R737.9 [医药卫生—肿瘤]
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共引文献12

同被引文献49

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临床检验杂志
2013年 第10期

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