胱抑素C和尿微量白蛋白联合检测在糖尿病并发肾损伤中的价值

Value of combined detection of serum cystatin C and urinary albumin excretion on diabetic pa- tients with renal injury

目的探讨胱抑素c和尿微量白蛋白检测在糖尿病并发肾损伤中的价值。方法通过对110例糖尿病患者进行跟踪监测（3年时间），其中并发肾损伤45例，未并发肾损伤65例。在实验初期和3年后分别检测110例患者的胱抑素C和尿微量白蛋白值，然后进行比较分析。结果3年后110例患者中胱抑素C和尿微量白蛋白均有不同程度升高，未并发肾损伤者胱抑素C和尿微量白蛋白升高明显，有早期肾损伤；并发肾损伤者，肾损伤呈进行性加重。结论对糖尿病患者采用胱抑素C和尿微量白蛋白联合监测肾损伤的发生比用其中一项监测更加及时、准确反映糖尿病并发症的发生、发展，为糖尿病并发症的预防及预后带来更大的治疗价值。

Objective To investigate the value of cystatin C and urinary albumin detecting on renal injury complicated by diabetes. Methods Tracking and monitoring 110 patients with diabetes in three years, including 45 patients with diabetic nephropathy and 65 patients only suffering from diabetes. Their cystatin C and urinary albumin were detected respectively at the beginning of the study and three years later, and then comparative anal- ysis was made. Results Three years later, the densities of cystatin C and urinary albumin increased in varying degrees. Among them, densities increased apparently for those without renal injury. While for those patients with early renal injury, their renal injury worsened as the time went on. Conclusions Comparing with the method that monitoring patients just though cystatin C or urinary albumin, detecting renal injury for diabetics via combing both of them is much more timely and accurate to reflect the occur- rence and development of complications from diabetes, which has more therapeutic value in preventing and prognosing complications from diabetes.