聚焦超声与药物治疗外阴上皮非瘤样病变的疗效比较

Comparison on the clinical efficacy of focused ultrasound and drugs in the treatment of vulvar intraepithelial neoplasia

目的观察聚焦超声与药物治疗外阴上皮非瘤样病变的效果。方法选取外阴上皮内非瘤样病变患者212例,根据随机数字表法分为观察组和对照组,各106例。观察组采用聚焦超声治疗,对照组选择雌三醇软膏与氢化可的松软膏治疗,比较两组治疗效果。结果观察组中的鳞状上皮增生型、硬化性苔癣型外阴上皮非瘤样病变的治愈率分别为96.8%和88.9%,均高于对照组相应类型的治愈率(χ2=5.103 1,4.189 0,P<0.05);观察组的总有效率为92.5%,高于对照组的70.8%,差异均具有统计学意义(χ2=13.335 0,P<0.05)。结论采用聚焦超声治疗外阴上皮非瘤样病变的效果优于采用药物治疗的效果,值得进一步推广。

Objective To investigate the clinical efficacy of focused ultrasound and drugs in the treatment of vulvar intraepithelial neoplasia.Methods A total of 212 patients with vulvar intraepithelial neoplasia were divided into the observation group and the control group,with 106 cases in each group.The observation group applied focused ultrasound,while the control used estriol ointment and hydrocortisone ointment.The therapeutic effects of the two groups were compared.Results In the observation group,the cure rates of squamous cell hyperplasia,lichen sclerosus type nonneoplastic epithelial disorders of vulva were 88.9% and 75.0%,respectively,significantly higher than those of the control group （x2=5.103 1,4.189 0,P〈0.05）.The total effective rate of the observation group was 90.6%,significantly higher than 70.8% of the control （x2=13.335 0,P〈0.05）.Conclusion In the treatment of vulvar intraepithelial neoplasia,the effect of focused ultrasound therapy were better than drugs,which is worthy of further promotion.