海南地区淋巴组织增生性病变病理分型与EBV感染的相关性分析

Exploration on the relationship between EB virus infection and the pathologic classification of lymphoproliferative disorders in Hainan.

目的分析海南地区淋巴组织增生性病变的病理分型及其与EB病毒感染的关系。方法收集我院最近5年淋巴组织增生性病变共524例,并对其中有完整资料的214例病例应用EB病毒编码小RNA(EBER)原位杂交检测淋巴组织中EB病毒(EBV)感染情况,分析EBV与不同类型淋巴瘤和淋巴结反应性增生的关系。结果 157例淋巴瘤进行了EBER检测,共有40例EB病毒(EBV)阳性,阳性率为25.48%,199例淋巴结反应性增生病变中,57例进行了EBER原位杂交检测,其中仅3例与EBV感染有关,阳性率为5.26%。结论 EBV与淋巴瘤,特别是T细胞淋巴瘤的发生有一定关系,以副皮质区增生为主的淋巴结反应性增生可能与EBV感染有关。

Objective To explore the relationship between Epstein-Barr virus （EBV） infection and the pathologic classification of lymphoproliferative disorders in Hainan.Methods In situ hybridization （ISH） for EBV-encoded small RNA （EBER） was performed to detect the infection of EBV in 214 patients,selected from 524 patients with lymphoproliferative disorders in our hospital in the recent 5 years.The relationship between EBV infection and the pathologic classification oflymphoproliferative disorders was analyzed.Results The positive cases of EBER in lym phoma （157 cases） was 40,with the positive rate of 25.48%,including 4 （3.96%） in 101 cases of B-cell non-Hodgkin lymphoma （B-NHL）,27 （61.36%） in 44 cases ofT-cell non-Hodgkin lymphoma （T-NHL）,and 9 （75%） in 12 cases of classical Hodgkin lymphoma mixed cellularity （CHL-MC）.The positive cases of EBER in lymph node reactive hyperplasia （57 of the 199 cases tested） was 3,with the positive rate of 5.26%.Conclusion There is a correlation between EBV infection and Lymphoma,especially T-cell lymphoma,and also between EBV infection and lymph node reactive hyperplasia