颈椎病中疼痛患者血清炎性细胞因子的变化及其临床意义

Change of cytokine in serum and pain in patients with cervical spondylosis and its clinical significance

目的 通过测定颈椎病中疼痛患者血清炎性细胞因子的含量,深入了解其病变.方法 选择2012年1～12月重庆市涪陵中心医院门诊和住院的颈椎病中疼痛患者48例为试验组.颈椎病根据临床症状结合CT和（或）MRI影像学检查确诊.选择成年健康体检者40例为对照组.应用放射免疫法测定血清中白细胞介素6、肿瘤坏死因子α的含量,应用酶联免疫法测定白细胞介素1β的含量.结果 试验组血清白细胞介素6、肿瘤坏死因子α、白细胞介素1β含量显著高于对照组[（131.78±32.06） pg/ml vs （108.85±41.48） pg/ml;（1.64±0.49） mol/ml vs（1.14±0.40） mol/ml;（0.40±0.17） pg/ml vs （0.19±0.06） pg/ml],差异有统计学意义（P＜0.05）.结论 颈椎病中疼痛患者炎症反应指标血清白细胞介素6、肿瘤坏死因子α、白细胞介素1β含量高于正常组,炎症细胞因子可能在颈椎病中疼痛患者椎间盘退变和疾病的发生发展中起重要作用.

Objective To analyze the expression ofcytokine in serum,so as to deepen the cognition of cervical spondylosis.Methods Forty-eight outpatients and inpatients with pain of cervical spondylosis selected from Chongqing Fuling Central Hospital from January to December 2012 were enrolled as the experimental group,who was diagnosed according to the clinical symptoms combined with CT and/or MR1 examination.Meanwhile,40 healthy individuals were selected as the control group.The content of interleukin 6 （IL-6） and tumor necrosis factor α TNF-a were determined with radioimmunology method.The content of interleukin 1β （IL-1β） were determined with enzyme immunology method.Results The content of IL-6,TNF α and IL-lβ in serum of the experimental group were significantly higher than the control group [（131.78±32.06） pg/ml vs （108.85±41.48） pg/ml; （1.64±0.49） mol/ml vs （1.14±0.40） mol/ml; （0.40±0.17） pg/ml vs （0.19±0.06） pg/ml,P〈0.05].Conclusion The contents oflL-6,TNF α and IL-1β in serum of patients with pain of cervical spondylosis are very high.Inflammation may play an important role in cervical disc degeneration and in the pathogenesis of cervical spondylosis.