肝前脂肪厚度与多囊卵巢综合征不孕症患者胰岛素抵抗的相关性研究

Correlation study among prehepatic fat thickness and insulin resistance in infertility patients with polycystic ovarian syndrome

目的探讨肝前脂肪厚度与多囊卵巢综合征(PCOS)不孕症患者胰岛素抵抗相关指标的关系,为PCOS不孕症的治疗提供相关依据。方法对91例PCOS不孕症患者行超声检测肝前脂肪厚度,并测量身高、体质量、腰围(WC)、臀围(HC)等指标,检测性激素、胰岛素等核医学指标;检测血脂、血糖等生化指标,分析肝前脂肪厚度与上述指标间的关系。结果肝前脂肪厚度与体质量、体重指数(BMI)、WC、HC等人体测量值呈正相关(P<0.05),与身高无明显相关(P>0.05);与空腹胰岛素、血糖、尿酸、胰岛素抵抗指数等呈正相关(P<0.05),与高密度脂蛋白呈负相关(P<0.05);与性激素、甲状腺功能、总胆固醇、甘油三酯、低密度脂蛋白及其他肝肾功能指标无明显相关(P>0.05)。结论肝前脂肪厚度在PCOS不孕症患者中与胰岛素抵抗有关的指标有一定的相关关系;在临床诊治该类患者时应全面评估,以提高妊娠率及改善妊娠结局。

Objective To study the correlation between prehepatic fat thickness and insulin resistance inde-xes in infertility patients with polycystic ovarian syndrome （ PCOS） , and to provide theoretic basis for the clinical di-agnosis and treatment of infertility patients with PCOS .Methods The prehepatic fat thickness were detected by ultra-sonography, and the height, weight, waist circumstance, the circle of hip line in 91 infertility patients with PCOS were measured, and sex hormones, insulin and thyroid hormones were detected, while the blood glucose, lipids, liver and renal function indexes were detected also .The relation among prehepatic fat thickness and the above indexes were analyzed.Results There was a positive correlation among the prehepatic fat thickness and weight , body mass index （BMI）, waist circumference, hip circumference（P〈0.05）, while no significant relation was found between prehe-patic fat thickness and height （ P〉0.05 ） .There was a positive correlation between the prehepatic fat thickness and fasting insulin, serum sugar, uric acid, insulin resistance index（P〈0.05）.There was a negative correlation among the prehepatic fat thickness and high-density lipoprotein （ P〈0.05 ） , while no significant relation was found among prehepatic fat thickness and sex hormones , thyroid hormones , total cholesterol , triglyceride , low density lipoprotein （ P〉0.05 ） .Conclus ion There is a certain correlation between prehepatic fat thickness and insulin resistance inde -xes in infertility patients with PCOS , a complete diagnostic evaluation should be conducted in such patients before clinical diagnosis and treatment so as to improve their pregnancy rate and pregnant outcomes .