肺炎支原体肺炎患儿治疗前后血清IL-2、IL-10、IL-18和D-D检测的临床意义

Clinical Significance of Measurement on Serum IL-2,IL-10,IL-18 and D-D Levels After Treatment in Pediatric Patients with Mycoplasma Pneumonia

目的:探讨了肺炎支原体肺炎患儿治疗前后血清IL-2、IL-10、IL-18和D-D水平的变化及临床意义。方法:应用放免法、酶联法和免疫比浊法对32例肺炎支原体肺炎患儿进行了治疗前后血清IL-2、IL-10、IL-18和D-D检测。并与35名正常健康儿比较。结果:肺炎支原体肺炎患儿在治疗前血清IL-2水平显著地低于正常儿组(P<0.01),而IL-10、IL-18和D-D水平又非常显著地高于正常儿组(P<0.01),经治疗1个月后则与正常儿组比较无显著性差异(P>0.05),且血清IL-2水平与IL-10、IL-18和D-D水平呈显著负相关(r=-0.4806、-0.5014、-0.5988,P<0.01)。结论:血清IL-2、IL-10、IL-18和D-D参与了肺炎支原体感染的全过程,检测这些细胞因子的变化有助于诊断、治疗和预后,具有一定的临床价值。

Objective To explore the clinical significance of changes on serum IL-2, IL-10, IL-18 and D-D levels after treatment in pediatric patients with mycoplasma pneumonia. Methods Serum IL-2 （ with RIA）, IL-2 （ with RIA）, serum IL-10, IL-18 （with ELISA）, serum D-D（with immunoturbidimetry） levels were determined in 32 patients with pediatric mycoplasma pneumonia patients and 35 normal healthy children. Results Before treatment, serum IL-2 level showed si^if;canfly lower than that in controls（P 〈0.01 ）. but serum IL-10, IL-18 and D-D levels were significantly higher than those in controls（P 〈 0.01 ）. After treatment for 2 weeks the levels in patients manifested no more different from those in controls（P 〉 0.05）. Serum IL-2 level was negative correlated with ser- um IL-10, IL-18 and D-D levels（r= -0.4806, -0.5014, -0.5988,P〈0.01）. Conclusion The cytokines IL-2, IL-10, IL-18 and D-D might participate in the whole process of mycoplasma infection, monitoring the changes of these cytokines could be helpful to the diagnosis, treatment and prognosis of the diseases and provides certain clinical values.