ACI患者治疗前后血清IL-2、IL-8、IL-18和VEGF检测的临床意义

Clinical Significance of Measurement the Changes on Serum IL-2,IL-8,IL-18and VEGF Levels After Treatment in Patients with Acute Cerebral Infarction

目的:探讨了急性脑梗死(ACI)患者治疗前后血清IL-2、IL-8、IL-18和VEGF水平的变化及临床意义。方法:应用放射免疫分析、酶联法对33例ACI患者进行了治疗前后血清IL-2、IL-8、IL-18和VEGF检测,并与35名正常健康人作比较。结果:ACI患者在治疗前血清IL-8、IL-18和VEGF水平非常显著地高于正常人组(P<0.01),而血清IL-2水平又非常显著地低于正常人组(P<0.01),经治疗3个月后与正常人组比较仍有显著性差异(P<0.05)。且血清IL-2水平与IL-8、IL-18和VEGF水平呈显著负相关(r=-0.4218、-0.4726、-0.5014,P<0.01)。结论:ACI的发生、发展与血清IL-2、IL-8、IL-18和VEGF水平密切相关。

Objective To explore the clinical significance of changes on serum IL-2, IL-8, IL-18 and VEGF levels after treatment in patients with acute cerebral infarction. Methods Serum IL-2, IL-8（with RIA） ; serum IL-18, VEGF（with ELISA） levels were detected in 33 patients with acute cerebral infarction both before and after treatment, as well as in 35 normal healthy controls. Re- suits Before treatment, the serum IL-8, IL-18, and VEGF levels in the patients proved significantly higher than those in controls（P 〈 0.01 ）, but serum IL-2 levels showed significantly lower（ P 〈 0.01 ） after 3 months treatment the levels though corrected markedly, remained significant difference from those in controls （P 〈 0.05 ）. Serum IL-2 levels were negatively correlated with serum IL-8, IL- 18, and VEGF levels（r= -0.4218, -0.4726, -0.5014,P〈0.01）. Conclusion Changes of serum IL-2, IL-8, IL-18 and VEGF levels might be closely related to the development and progress of acute cerebral infarction.