摘要
目的观察经络舒胶囊对糖尿病动物坐骨神经山梨醇(多元醇)代谢通路的影响。方法通过复制链脲佐菌素性糖尿病动物模型,观察经络舒胶囊对糖尿病后坐骨神经出现的多元醇代谢通路、超氧化物歧化酶(SOD)、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-PX)水平紊乱的改善作用。结果 (1)经络舒高剂量组对糖尿病后坐骨神经的传导速度及动作电位不应期有明显的保护作用,可明显提高糖尿病动物模型坐骨神经的传导速度,缩短其动作电位不应期(P<0.05)。(2)对糖尿病大鼠坐骨神经MDA及山梨醇水平升高有降低作用(P<0.01,P<0.05);可提高GSH-PX、SOD活性(P<0.01,P<0.05)。结论经络舒胶囊有一定的抑制糖尿病动物模型坐骨神经多元醇代谢的作用。
Objective To observe the effects of Jingluoshu Capsule on sciatic nerve polyol metabolic pathway in diabetic animals. Methods On streptozotocin-induced diabetic animal model, we observed the effect of Jingluoshu Capsule on sciatic nerve polyol pathway and on superoxide dismutase（SOD）, rualondialdehyde（MDA）, glutathione peroxidase（GSH-PX） levels. Results （1）Jingluoshu capsule had obvious effect on increasing conduction velocity and shortening refractory period of sciatic nerve action potential in diabetic animal, and improved the pathological changes of sciatic nerve（P 〈 0.05）. （2） Jingluoshu capsule had an effect on decreasing the levels of MDA and sorbitol in sciatic nerve of diabetic animal, and could enhance the activities of GSH-PX and SOD （P 〈 0.01, P 〈 0.05）. Conclusion Jingluoshu Capsule shows certain inhibitory effect on the hyperactivity of polyol metabolism in the STZ-induced diabetic animals
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第6期582-584,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
贵州省中药现代化科技产业研究开发专项项目(黔科合农字[2005]5001号)
