摘要
目的研究五色梅(Lantana camara Linn.)的三萜类化学成分。方法采用硅胶、Sephadex LH-20、ODS反向硅胶等柱色谱方法进行分离纯化,并根据化合物的理化性质和波谱数据鉴定其结构。结果分离并鉴定了11个三萜类化合物,分别为:马缨丹甲素(1)、马缨丹乙素(2)、齐墩果酮酸(3)、羽扇豆醇乙酸酯(4)、3β-乙酰基齐墩果酸(5)、齐墩果酸(6)、3-O-乙酰坡模醇酸(7)、3β,25-epoxy-3α,21α-dihydroxy-22β-angeloyloxyolean-12-ene-28-oic acid(8)、白桦脂酸(9)、2α,3α,19-三羟基-12-烯-28-乌苏酸(10)、12-齐墩果烯-3β,24-二羟基-22-酮(11)。结论化合物4,5,7-11均为首次从该植物中分离得到。
OBJECTIVE To study the chemical constituents of triterpenoids from Lantana camara Linn. METHODS The com- pounds were isolated and purified by repeated column chromatography on silica gel, Sephadex LH-20 and ODS. Their structures were i- dentified by physicochemical properties and spectroscopic analysis. RESULTS Eleven compounds were isolated and identified as lan- tadene A ( 1 ) , lantadene B ( 2 ), oleanonic acid ( 3 ), lupeol acetate ( 4 ), 3β--acetyloleanolic acid ( 5 ) , oleanolic acid ( 6 ), 3-O-acetyl pomolic acid (7), 3/3, 25-epoxy-3α, 21α-dihydroxy-22/3-angeloyloxyolean-12-ene-28-oic acid ( 8 ), betulinic acid ( 9 ) , 2α, 3α, 19-trihy- droxy-12-en-28-ursolic acid ( 10), 22-oxo-3β-,24-dihydroxyolean-12-ene ( 11 ). CONCLUSION Compounds 4,5,7 - 11 are isolated from this plant for the first time.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2013年第23期1990-1993,共4页
Chinese Pharmaceutical Journal
基金
广东食品药品职业学院科研资助项目(2010YZ012)