超声声化学激活血卟啉效应的研究

Sonochemically active effect on hematoporphyrin

本文用 1,3 二苯基异苯并呋喃 (DPBF)检测了超声激活血卟啉的效率 ,并寻找了声参量与激活效率之间的关系。结果表明 ,在一定条件下 ,DPBF的相对消耗量随着辐照时间、声强度的增大而增大 ,超声频率及血卟啉浓度对DPBF相对消耗量也有影响。这一结果为声动力学疗法应用于临床具有重要的意义。

By using 1,3 diphenylisobenzofuran (DPBF),the activating efficiency of hematoporphyrin (HPD) by ultrasound has been detected and the relations of acoustic parameters with the activating efficiency have been found.The results show that under a certain condition, the relative loss of DPBF will rise up with the increasing of insonation time and acoustic intensity.Moreover the acoustic frequency and HPD concentration have influenced on the relative loss of DPBF.The result is of great significance for driving sonodynamic treatment to clinic application.