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STAT3异常磷酸化在血液系统肿瘤中的作用

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摘要 STAT3(signal transducer and activator of transcription 3)在细胞增殖、分化、存活、凋亡、细胞免疫等多种生理病理过程中发挥关键性作用。STAT3异常磷酸化与肿瘤形成密切相关。STAT3异常磷酸化在肿瘤形成中可能发挥了重要作用。本文就STAT3异常磷酸化在血液系统肿瘤形成中的作用做一简单综述。
出处 《医药论坛杂志》 2013年第12期140-141,共2页 Journal of Medical Forum
基金 北京市科委首都特色临床医学技术发展研究基金(Z080507030808010)
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参考文献17

  • 1Aggarwal BB, Kunnumakkara AB, Harikumar KB, et al. Signal transducer and activator of transcription - 3, inflammation, and cancer:how intimate is the relationship[J] Ann N Y Acad Sci, 2009,1171:59-76.
  • 2Akira S. Roles of STAT3 defined by tissue - specific gene targe- ting[ J ]. Oncogene ,2000,19 (21) :2607-11.
  • 3Steelman LS, Abrams SL, Whelan J, et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT path- ways to leukemia[ J ]. Leukemia,2008,22 (4) :686-707.
  • 4韩春生,陈艳,伍学强.STAT3在肿瘤形成中的作用[J].中国实验血液学杂志,2013,21(2):517-520. 被引量:17
  • 5马玲娣,周民,蒋丽佳,岑玲,范静,夏蕾.STAT3基因沉默抑制人白血病细胞体外生长的实验研究[J].南京医科大学学报(自然科学版),2011,31(2):149-155. 被引量:1
  • 6Zhao~ J, Xu Y, Zong Y, et al. Inhibition of Star3 expression in- duces apoptosis and suppresses proliferation in human leukemia HL - 60 cells[J]. Hematology, 2011,16 (4) : 232-5.
  • 7李惠丽.STAT_3基因在急性淋巴细胞白血病细胞中的表达及意义[J].吉林医学,2010,31(15):2163-2164. 被引量:3
  • 8Mitchell TJ,John S. Signal transducer and activator of transcrip- tion(STAT) signalling and T - cell lymphomas [ J ]. Immunolo- gy ,2005,114(3) :301-12.
  • 9Nelson EA, Walker SR, Kepich A, et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STA'I~ [ J]. Blood,2008,112 ( 13 ) :5095-102.
  • 10Ghoshal Gupta S, Banmann H, et al, Epigenetic regulation of sig- nal transducer and activator of transcription 3 in acute myeloid leukemia[ J]. Leuk Res,2008,32(7 ) : 1005-14.

二级参考文献48

  • 1张彦,马凌娣,何於娟,蒋纪恺.苦参碱诱导K562细胞分化早期的基因表达分析[J].中华血液学杂志,2004,25(6):342-345. 被引量:18
  • 2陈秀英,卢春,程林,曾怡,姚水洪,秦娣.卡波济肉瘤相关疱疹病毒编码IL-6基因的分离克隆及在NIH3T3细胞中的表达研究[J].南京医科大学学报(自然科学版),2006,26(10):881-886. 被引量:6
  • 3仲跻巍,刘现忠,姚爱华,浦立勇,李相成.缺血预处理对于大鼠部分肝移植术后肝再生信号通路的影响[J].南京医科大学学报(自然科学版),2007,27(7):724-728. 被引量:3
  • 4Levy DE,Darnell JE Jr.Statsrtranscriptional control and biological impact[J].Nat Rev Mol Cell Boil,2002,3(9):651.
  • 5Buettner R,Mora LB.Jove R.Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention[J].Clin Cancer Res,2002,8(4):945.
  • 6Niu G,Wright KL,Huang M,et al.Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis[J].Oncogene,2002,21(13):2000.
  • 7Bowman T.Garcia R,Turkson J,et al.gene,2000,19(21):2474.
  • 8Aggarwal BB, Kunnumakkara AB, Harikumar KB.Signal transducer and activator of transcription-3, inflammation, and cancer[ J ]. Ann NY Acad Sci, 2009,1171 : 59-76.
  • 9Benekli M, Baumann H, Wetzler M. Targeting signal transducer and activator of transcription signaling pathway in leukemias [J]. J Clin Oncol,2009,27(26): 4422-4432.
  • 10Bewry NN, Nair RR, Emmons MF. Star3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance[J]. Mol Cancer Ther, 2008,7(10) :3169-3175.

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