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S100A9蛋白在脓毒症中作用的研究进展

Advance on $100A9 in sepsis
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摘要 背景S100A9及其结合伴侣S100A8,是S100钙结合蛋白家族的重要成员,具有多种生物学功能。目的介绍近年来针对S100A9在脓毒症中作用的研究进展,探讨其对免疫功能调节的作用及机制。内容对S100A9蛋白的特点、受体及介导的信号通路、活化中性粒细胞的趋化和黏附功能,以及在脓毒症中的作用等内容进行概述。趋向过去对S100蛋白的研究侧重于慢性炎症和肿瘤,目前的研究更多地关注S100蛋白与急性炎症的关系。S100A9在脓毒症中的作用机制复杂,研究表明S100A9等蛋白具有抗炎、抗氧化的保护作用。进一步的研究将帮助我们更好地理解S100A9等炎症相关蛋白,以期对脓毒症的临床免疫调节治疗提供了新的思路和方向。 Background S100A9 and its binding partner S100A8 are important members of S100 calcium-binding protein family, which have extensive functions and participate in multiple biological processes. Objective This review aims to provide research progerss of S100A9 in sepsis, and also to discuss its role in immune regulation, as well as the mechanisms. Content This review includes the following aspects about S100A9: characteristics, receptors and signaling pathways, mediating chemotaxis and adhesion of neutrophils, and its role in sepsis. Trend There has been plenty of studies on S100 proteins in chronic inflammation and cancer in the past decade. Now more and more studies are focusing on the proteins' role in acute inflammation. The mechanism of S100A9 in sepsis is very complex. It has been proved that S100A8 and S100A9 have anti-oxidative and anti-inflammatory effect. Further research need to be done to help us understanding the protein better, and it may provide new prospective and direction for sepsis treatment.
出处 《国际麻醉学与复苏杂志》 CAS 2013年第12期1117-1119,1127,共4页 International Journal of Anesthesiology and Resuscitation
关键词 S100A9 脓毒症 中性粒细胞 TOLL样受体4 S100A9 Sepsis Neutrophils Toll like receptor-4
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