期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

缝隙连接蛋白43与心肌缺血／再灌注损伤机制的研究进展

Progress in gap junctional connexin 43 and myocardial ischemia/reperfusion injury
原文传递
导出
摘要 背景研究表明，心肌缺血／再灌注（ischemia／reperfusion，I／R）损伤的发病机制与氧自由基过量产生、钙超载、线粒体损伤及心肌细胞凋亡等密切相关，最新研究发现缝隙连接（gapjunction，GJ）也参与心肌I／R损伤。目的现主要针对GJ连接蛋白（connexin，Cx）43与心肌I／R损伤的关系作一综述。内容Cx43在心肌I／R损伤中参与心肌保护作用，其机制可能与钙超载、在线粒体中的分布及细胞凋亡等因素相关。趋向未来研究需要进一步探究Cx43与心肌细胞凋亡之间的关系，同时为临床实际工作提供依据。 Background The mechanism of myocardial ischemia/reperfusion （I/R） involves in peroxidation, calcium overload, mitochondria injury, myocardial cells apoptosis and so on. Recent sdudies indicate that the gap junctional（GJ） intercellular communication of myocardial cells may play a role in myocardial I/R injury. Objective This article summarized the relationship between the GJ connexin （Cx） 43 and myocardial I/R injury. Content Cx43 could protected myocardium from I/R injury. The mechanism may be related with calcium overload, mitochondria injury, myocardial cells apoptosis and so on. Trend Researches in future should be taken to further explore of the relation between Cx43 and apoptosis, and strengthen the cilinial applications.
作者 韩霜 容俊芳
机构地区 河北省人民医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2013年第12期1139-1141,共3页 International Journal of Anesthesiology and Resuscitation
关键词 连接蛋白43 缝隙接合部 心肌再灌注损伤 Connexin 43 Gap Junctions Myocardial reperfusion injury
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献21

  • 1Dhein S, Hagen A, Jozwiak J, et al. Improving cardiac gap junction communication as a new antiarrhythmic mechanism: the action of antiarrhythmic peptides. Naunyn Schmiedebergs Arch Pharmacol, 2010, 381(3): 221-234.
  • 2Delmar bl , Makita N. Cardiac eonnexins , mutations and arrhythmias. Curr Opin Cardiol, 2012, 27(3): 236-241.
  • 3Janczarska K, Kiec-Wilk B, Leszczyflska-Golabek I, et al. The role of connexin 43 in preconditioning. Impact on mitochondrial function. Kardiol Pol, 2010, 68( 1 ) : 91-96.
  • 4Danon A, Zeevi-Levin N, Pinkovich DY, et al. Hypoxia causes connexin 43 internalization in neonatal rat ventricular myocytes. Gen Physiol Biophys, 2010, 29(3): 222-233.
  • 5Li C, Meng Q, Yu X, et al. Regulatory effect of connexin 43 on basal Ca2+ signaling in rat ventrieular myocytes. PLoS One, 2012, 7(4): e36165.
  • 6Garcfa-Dorado D, Rodrfguez -Sinovas A, Ruiz -Meana M. Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res, 2004, 61(3): 386-401.
  • 7Salameh A, Krautblatter S, Karl S, et al. The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta- adrenoceptors. Br Pharmacol, 2009, 158 (1): 198-208.
  • 8Wang N, De Bock M, Antoons G, et al. Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca^2 + elevation. Basic Res Cardiol, 2012, 107 (6): 304.
  • 9Baumgartner HK, Gerasimenko JV, Thome C, et al. Calcium elevation in mitochondria is the main Ca^2+ requirement for mPTP opening. J Biol Chem, 2009, 284(31): 20796-20803.
  • 10Goubaeva F, Mikami M, Giardina S, et al. Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys Res Commun, 2007, 352(1): 97-103.

二级参考文献37

  • 1陈宝平,毛红娇,范芳燕,李江,夏强.缝隙连接脱耦联剂庚醇对大鼠缺血-再灌注损伤心肌的保护作用[J].中国病理生理杂志,2005,21(6):1071-1075. 被引量：8
  • 2苏德淳,常志文,范书英.缝隙连接在大鼠缺血预适应心肌保护中的作用[J].中华心血管病杂志,2006,34(8):690-694. 被引量：13
  • 3Schulz R, Boengler K, Dodoni G, et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning[ J]. Cardiovasc Res, 2005, 67 (2) : 234 - 244.
  • 4Paradies G, Petrosilto G, Pistolese M, et al. Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin[J]. Circ Res, 2004, 94(1): 53-59.
  • 5Flameng W, Borgers M, Daenen W, et al. Uhrastructural and cytochemical correlates of myocardial protection by cardiac hypothermia in man [ J ]. J Thorac Cardiovasc Surg, 1980, 79(3): 413-424.
  • 6Emaus RK, Grunwald R, Lemaslers JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat liver mitochondria: spectral and metabolic properties [ J ]. Biochim Biophys Acta, 1986, 850(3) : 436 -448.
  • 7Elizabeth AF, James DM, Takttro T, et al. Myocardial mitochondrial calcium accumulation modulates nuclear cal- cium accumulation and DNA. fragmentation [ J ]. Amm Thorac Surg, 1995, 60(2) : 338 -344.
  • 8Baumgartner HK, Gerasimenko JV, Thorne C, et al. Calcium elevat ion in mitochondria is the main Ca^2+ requirement for mPTP opening [ J ]. J Biol Chem, 2009, 284 ( 31 ) : 20796 - 20803.
  • 9Penna C, Perrelli MG, Raimondo S, et al. Postconditioning induces an anti - apoptotic effect and preserves mitochondrial integrity in isolated rat hearts[ J]. Biochim Biophys Acta, 2009, 1787 (7) : 794 - 801.
  • 10Cruciani V, Mikalsen SO. Connexins, gap junctional intercellular communication and kinases [ J ]. Biol Cell, 2002, 94(7 -8) : 433 -443.

共引文献12

国际麻醉学与复苏杂志
2013年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部