消敏合剂对慢性变应性接触性皮炎小鼠脾指数、胸腺指数以及组织病理学的影响

Xiaomin Mixture Effect on Mice Spleen Index,Thymus Index and Histopathology of Chronic Allergic Contact Dermatitis Mice

目的 :探讨消敏合剂对2,4-二硝基氯苯(DNCB)诱导的慢性变应性接触性皮炎小鼠脾指数,胸腺指数以及组织病理学的影响。方法 :利用DNCB诱导建立慢性变应性接触性皮炎小鼠动物模型,观察消敏合剂对小鼠脾指数和胸腺指数的影响,HE染色光镜下逐一观察各组皮肤组织学改变。结果 :消敏合剂具有抑制DNCB诱导的慢性变态性接触性皮炎小鼠脾指数和胸腺指数的作用,局部组织炎性细胞浸润减轻。结论 :消敏合剂能够改善DNCB诱导的慢性变态性接触性皮炎小鼠的局部炎症反应,具有一定的抗炎作用。

Objective：To investigate the effect of Xiaomin Mixture on spleen index,thymus index and histopathology of 2,4-dinitrophenol niro chlorobenzene induced chronic allergic reaction dermatitis in mice.Methods：ACD model by DNCB induction was established.The effect of Xiaomin Mixture on the spleen index and thymus index were observed under the light microscope observation of skin tissue pathological changes by HE staining in each group.Results：Xiaomin Mixture on chronic allergic contact dermatitis in mice can inhibit the spleen index and thymus index, reducinglocal tissue inflammatory cell infiltration.Conclusion：Xiaomin Mixture can improve local inflammatory reactiona nd has anti-inflammatory effect.