中医药综合辨证治疗对中晚期恶性肿瘤生存质量影响

Effects of Chinese Medicine Comprehensive Therapy on Quality of Life of Malignant Tumor Patients with Middle-Advanced Stage

目的 :观察中医药综合疗法对中晚期恶性肿瘤临床疗效及生存质量的影响,为进一步研究提供临床依据。方法 :对60例中晚期肿瘤患者采用辨证论治为主体的综合治疗方案,以28 d为1个周期,治疗2个周期,观察治疗后临床获益、生存质量改善情况及不良反应。结果 :治疗后患者中医症状积分改善率达55.3%,证候疗效达到有效,疼痛总有效率为95.9%,KPS评分及体质量均有明显改善,总有效率分别为81.7%和76.7%。功能子量表中躯体、情绪、认知、社会功能,治疗后与治疗前相比有明显提高,症状子量表中在疲劳、恶心呕吐、疼痛、失眠、食欲丧失5个方面有显著改善,差异均有统计学意义(P<0.05)。结论 :中医药综合疗法可以改善中晚期肿瘤患者临床症状,提高生存质量,具有潜在的优势。

Objective ： To observe the effects of Chinese medicine comprehensive therapy on quality of life of malignant tumor patients with middle-advanced stage, providing clinical evidence for further studies. Methods： 60 tumor patients were given comprehensive therapy. The treatments were based on overall analysis of symptoms and signs were the main part. Twenty-eighl days was one therapeutic course, and two courses in total. The clinical benefits and improvments of quality of life and adverse reaction were observed after treatment. Results ： After treatment, the improvement rate of symptom integral was 55.3%, and the curative effect of syndrome reached to effective level. The total effective rate of pain was 95.9%, and that of KPS score and body weight were 81.7% and 76.7% separately. In functional scales, the scores of physiology, sensibility, reeognization and society were superior to that before treatment. In symptom scales, the scores of fatigue, nausea and vomiting, pain, somnipathy and anorexia were increased significantly. All showed statistical difference （ P〈0.05 ）. Conclusions ： Chinese medicine comprehensive therapy could improve clinical symptoms as well as quality of life of malignant tumor patients with middle-advanced stage. It showed potential superiority.