PD-1及其配体在心脏、神经疾病中的研究进展

Research Progress of PD-1 and Its Ligands in Heart and Nervous Diseases

程序性死亡因子1(PD-1)是免疫球蛋白超家族激活诱导的抑制性受体,它有两个配体:PD-L1和PD-L2。PD-1与其配体PD-L结合后,可调节T细胞的活化及分化,抑制T细胞增殖,发挥对效应T细胞的负性调控作用,参与多种免疫过程,并在动脉硬化、心脏及神经疾病的发生和发展过程中扮演重要角色,因此近年来受到广泛的关注。该文就PD-1/PD-L在动脉硬化、心脏及神经疾病的研究进展予以综述。

Abstract：Programmed death-1 （PD-1）molecule is the immunoglobulin superfamily induced inhibitory receptor,and PD-L1 and PD-L2 are the two ligands of PD-1. PD-1 delivers a negative costimulatory signal to effector T cells by engagement with its ligands, inhibits T cell activation, cytokine production and prolifera- tion, prevents excessive immune injury and autoimmune diseases, such as atherosclerosis, heart disease and nervous disease. Here is to make a review of the research progress of PD-1/Pd-L in atherosclerosis,heart and nervous diseases.