布地奈德与特布他林联合治疗小儿过敏性支气管炎的临床疗效探讨

The Clinical Curative Effect of Budesonide Combined with Terbutaline in Treating Pediatric Allergic Bronchitis

目的探讨布地奈德联合特布他林治疗小儿过敏性支气管炎的临床疗效。方法将2011年4月至2013年4月广州中医药大学附属南海区妇幼保健院儿内科收治的112例过敏性支气管炎患儿依据随机数字表法分为两组:观察组(57例)给予布地奈德联合特布他林雾化吸入治疗,对照组(55例)给予沙丁胺醇口服治疗,两组均给予常规抑制炎性反应及对症支持治疗。比较两组的临床疗效、咳嗽评分及肺功能的变化差异。结果观察组有效率高于对照组(89.27%vs 63.36%),差异有统计学意义(P<0.05);治疗后,两组的咳嗽评分均较治疗前降低,且观察组咳嗽评分降低程度显著优于对照组(P<0.05);治疗后,两组肺功能指标(FEV1、FVC、MMEF)均较治疗前有所增高,且观察组肺功能指标增高程度显著优于对照组(P<0.05)。结论布地奈德联合特布他林治疗小儿过敏性支气管炎的临床疗效显著,值得临床推广使用。

Objective To explore the clinical curative ef[ect of budesonide combined with terbutaline on treating pediatric allergic bronchitis. Methods From Apr. 2011 to Apr. 2013,112 cases of children with allergic bronchitis admitted to Nanhai District Maternal and Child Health Care Hospital were randomly divid- ed into two groups. The observation group of 57 cases was treated with budesonide combined with terbutaline. The control group of 55 cases was treated with inhalation of salbutamol. Both groups were given conventional. inhibition of inflammatory reaction, symptomatic and supportive treatment, then the clinical efficacy, cough scores and lung function change differences of the two groups were compared. Results Efficacy of the obser- vation group was higher（ 89.27% vs 63.36% ）, the difference was statistically significant （P 〈 0.05 ） ;after treatment, cough score of both groups were lower than before treatment, and the lower level of the observation group was betterthan the control group, with statistically significant difference （ P 〈 0.05 ） ; after treatment, lung function（ FEV1 , FVC, MMEF）has increased than before treatment ,and the increased level of the obser- vation group better than the control group with statistically significant difference（ P 〈 0.05 ）. Conclusion Budesonide combined with terbutaline treating pediatric allergic bronchitis has significant clinical effect, which is worthy of clinical use.