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胸苷激酶1在妇科恶性肿瘤中的研究进展

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摘要 1胸苷激酶的结构和功能细胞增殖和分裂过程中的调控机制紊乱是恶性肿瘤发生发展的根本原因。胸苷激酶(TK)在Mg2+参与下催化ATP末端磷酸基团转移到胸苷5-OH上形成dTMP,dTMP是dTTP合成的重要原料,因而TK在DNA合成补救途径中发挥重要作用,作为哺乳动物细胞分裂增殖中的一个重要调控者,
作者 叶伟 周家德
出处 《安徽医学》 2013年第5期668-670,共3页 Anhui Medical Journal
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