个体化^(131)I剂量治疗Graves病并发症的疗效分析

Clinical retrospective analysis of individual-dose radioiodine-131 therapy for the complications of Graves' disease

目的探讨个体化131I剂量治疗Graves病相关并发症的疗效。方法回顾性分析431例131I治疗的Graves病患者临床随访资料,其中合并甲亢性突眼177例,甲亢性心脏病35例,甲亢性肝功能损害82例及周期性麻痹9例。给予甲状腺组织(7.26±3.68)MBq/g的个体化131I剂量治疗,随访1年。结果131I治疗后1年,177例甲亢性突眼患者中,67例治愈(37.85%),56例好转(31.64%),48例无效(27.12%),6例加重(3.39%);35例甲亢性心脏病患者中,27例治愈(77.14%),8例好转(22.86%);82例甲亢性肝功能损害患者中,69例治愈(84.15%),13例好转(15.85%);9例周期性麻痹患者中,8例治愈(88.89%),1例好转(11.11%)。结论131I对Graves病并发症的治疗安全、有效。

Objective To investigate the treatment effects of individual dose 131I therapy for the complications of Graves＂ disease. Methods Four hundred and thirty one cases with Graves＇disease who accepted individual dose 131I therapy, were retrospectively studied, of whom 177 patients were with hyperthyroid ophthalmopathy, 35 patients with hyperthyroid heart disease, 82 patients with hyperthyroid liver damage, and 9 patients with periodic paralysis. Graves＂ disease patients were given individual dose 1311 of mean （ 7.26 ±3.68 ） MBq per ram of thyroid tissue. The term of follow up was one year. Results After 1311 therapy, of the 177 cases with hyperthyroid ophthalmopathy,67 cases were cured（37.85% ）, 56 cases were improved （31.64%）, 48 cases were invalid （27.12%）, and 6 case was aggravated （3. 39% ） ; of the 35 cases with hyperthyroid heart disease, 27 cases were cured（77.14% ）, 8 cases were improved（22.86% ） ; of the 82 cases with hyperthyroid liver damage, 69 cases were cured（ 84.15% ）, and 13 cases were improved（ 15.85% ） ; of the 9 cases with periodic paral ysis, 8 cases were cured （ 88.89% ）, and 1 case was improved（ 11.11% ）. Conclusion The individual dose 131 I therapy for the complica tions of Graves＂ disease is effective and safe.