低剂量叶酸预防子痫前期的作用

Role of Folic Acid Supplementation during Pregnancy in Reducing Risk of Developing Pre-eclampsia

目的探讨孕产妇口服叶酸片预防子痫前期的作用。方法 2012年1月至2012年12月在我院分娩的符合研究纳入标准的孕产妇2908例,分为两组,一组为有规律服用叶酸片的孕产妇2036例,另一组为无服用叶酸片的孕产妇872例。对其各自的子痫前期发生率进行统计。结果 2908例孕产妇中发生子痫前期90例(3.1%),其中2036例口服叶酸的孕产妇发生子痫前期43例(2.1%),872例无口服叶酸的孕产妇发生子痫前期47例(5.4%),两组间发生率差异有统计学意义(P<0.05)。结论口服叶酸片的孕产妇子痫前期的发生率比无口服叶酸片的孕产妇发生率低,口服叶酸片对预防子痫前期的发生具有一定的作用。

Objective To explore the relationship between folio acid supplementation during pregnancy and the risk of Pre-eclampsia. Method 2908 cases of pregnant women, who delivered in our hospital, were divided into two groups. The first group was 2036 cases of pregnant women who regularly took low dose of folic acid by oral; another group was 872 cases of pregnant women who did not take folic acid. The risks of Pre-eclampsia were compared. Result There were 90 cases developed to Pre-eclampsia in 2908 cases of pregnant women （3.1%）. The risk of developing Pre-eclampsia in the first group was 2.1% （43 cases）, the second group was 5.4% （47 cases）.There were significantly differences in the risks of these two groups （P〈0.05）. Conclusion Low dose of folic acid supplementation during pregnancy can reduce the risk of developing Pre-eclampsia.