86例咳嗽变异性哮喘儿童的随访研究分析

The Follow up Study of 86 Children with Cough Variant Asthma

目的探讨咳嗽变异性哮喘(CVA)患儿发展为典型哮喘的比例及相关危险因素。方法对2009年10月至2010年10月在郑州市儿童医院就诊的86例CVA患儿进行2年随访,计算其中出现喘息的比例,并对相关因素进行统计分析。结果经过2年随访研究,86例CVA患儿中29例患儿发展为典型哮喘,喘息率为33.7%。29例发展为典型哮喘患儿中有18例患儿对尘螨过敏,57例非哮喘患儿中20例对尘螨过敏,两组比较差异有统计学意义(P=0.023)。结论 CVA患儿随访2年有33.7%患儿出现喘息,尘螨过敏可能是CVA发展为典型哮喘的危险因素。

Objective To evaluate the predictors for risk of asthma onset from cough variant asthma （CVA）.Methods The follow-up study was conducted in Asthma Center of Zhengzhou Children＇s Hospital between October 2009 and October 2010. 86 CVA children were recruited into this study. The children had been studied for two years to ascertain whether asthma developed or not. Results After 2 years of follow up assessment, 29（33.7%）of the 86 children with CVA developedasthma. Results of logistic analysis showed that allergic to dust mites （adjusted OR 2.945, P=0.023） was a risk factor for asthma onset from cough variant asthma. Conclusion Sensitive to dust mites may be a risk factor for the development of asthma in children with CVA.