血浆D-二聚体结合纤维蛋白原测定诊断肺栓塞的临床意义分析

The Plasma D-two Dimer Binds Fibrinogen Determination Clinical Significance in the Diagnosis of Pulmonary Embolism Analysis

目的探讨血浆D-二聚体(D-D)结合纤维蛋白原(Fg)测定在诊断肺栓塞中的临床意义。方法对42例临床确诊为肺栓塞的患者进行D-二聚体、纤维蛋白原测定并与正常健康对照组比较。结果肺栓塞组患者血浆D-二聚体和纤维蛋白原水平显著高于正常对照组,差异有显著统计学意义(P<0.05),单独测定D-二聚体的灵敏度、特异性分别为85.8%和42.5%;单独测定纤维蛋白原的灵敏度和特异性分别为70.2%和34.2%,而两者联合测定对诊断肺栓塞的灵敏度和特异性显著上升,分别为95.4%和56.8%。结论血浆D-二聚体结合纤维蛋白原测定对诊断肺栓塞有重要的临床价值,有利于提高肺栓塞的诊断率。

Objective To evaluate the clinical value of testing D-dimer and fibrinogen in patients with pulmonary embolism. Methods D-dimer and fibrinogen of 42 patients with pulmonary embolism were determined. The data of the D-dimer and fibrinogen were analyzed and compared with the compared group. Results Comparing with the compared group, Level of D-dimer and fibrinogen in pulmonary embolism group showed great differences（P〈0.05）. The sensitivity rates of D-dimer and fibrinogen in pulmonary embolism were 85.8%,70.2% respectively, the sepcific rates were 42.5%,34.2% respectively, while sensitivity and specificity of combined testing were respectively 95.4%and56.8%. Conclusion Combined testing of plasma D-dimer and fibrinogen has great clinical significance in the final diagnosis of pulmonary embolism.