曲美他嗪治疗急性心肌梗死的临床探讨

The Clinical Study of Trimetazidine Treatment of Acute Myocardial Infarction

目的分析曲美他嗪用于治疗急性心肌梗死的临床效果。方法收集急性心肌梗死患者92例,随机分为观察组与对照组,观察组早期服用曲美他嗪,对照组予以常规治疗。结果观察组的心电图ST段下降幅度显著高于对照组;观察组的CK及CK-MB峰浓度显著低于对照组,达到峰值及恢复正常的时间显著短于对照组;观察组的LVEF较入院时显著升高,BNP显著降低;与对照组比较差异显著(P<0.05);两组均未发现明显不良反应。结论对急性心肌梗死患者在再灌注前应用曲美他嗪治疗,可改善患者的心电图。

Objective To analysis oftrimetazidine is used in the treatment of the clinical effect of acute myocardial infarction. Method Collecting 92 cases of patients with acute myocardial infarction （mi）, were randomly divided into observation group and control group and observation group take trimetazidine early, the control group with conventional treatments. Results The ecg ST segment drop in observation group was significantly higher than the control group; Observation group of CK and CK-MB peak concentration significantly lower than the control group, peak and return to normal time was significantly shorter than control group; A significant rise in observation group of LVEF is hospitalized, the BNP decreased significantly; Compared with the control group significant difference （P〈0.05）; In the two groups were not found obvious adverse reactions. Conclusion In patients with acute myocardial infarction before reperfusion trimetazidine treatment, can improve the patient＇s eeg.